Kno2
About
Kno2 is a full-stack healthcare communication network and federally designated Qualified Health Information Network (QHIN) under TEFCA that connects clinical systems, EHRs, data, and workflows across the healthcare ecosystem. The company provides a single Communication API and a web-based portal (Kno2fy) that enable providers, payers, health IT vendors, and patients to securely exchange clinical information using standards including fax, Direct Secure Messaging, FHIR, and HL7. Kno2 is described ...
Details
VenSearch Intelligence
Ideal Customer
- Kno2 serves a broad range of customer sizes, from single-provider offices and small specialty clinics to large health systems and major EHR vendors.
- Its subscription-based Kno2fy portal targets smaller and mid-sized provider organizations that need turnkey interoperability without building custom integrations, while its Communication API is designed for technology vendors — EHRs, digital health platforms, payers, and HIEs — of any size seeking a single integration point to the full healthcare communication ecosystem.
Key Differentiators
- Kno2's primary differentiator is its position as the nation's largest healthcare communication network and one of the first organizations to receive federal QHIN designation under TEFCA — placing it alongside Epic, CommonWell, and eHealth Exchange in a very small cohort of nationally designated networks.
- Unlike point solutions, Kno2 offers a single Communication API that consolidates every major exchange channel (TEFCA/QHIN, Carequality, Direct Secure Messaging, FHIR, HL7 V2, cloud fax, HIE, referral networks, and eSigning) into one integration, eliminating the need for separate vendor relationships per channel.
Industries Served
- Kno2 operates exclusively within the U.S. healthcare industry, serving providers (hospitals, health systems, ambulatory practices, post-acute/long-term care, behavioral health, EMS, vision, dental, home health, and specialty clinics), payers, and health IT/technology vendors (EHRs, digital health platforms, remote patient monitoring, population health, and office technology vendors).
- The company holds a federal QHIN designation under TEFCA from the Office of the National Coordinator for Health Information Technology (ONC), is a Carequality implementor, and participates in the CMS Aligned Networks initiative — all healthcare-specific regulatory frameworks.
Service Coverage
- Kno2 operates as a nationwide U.S. healthcare communication network headquartered in Boise, Idaho, with no significant international operations publicly documented.
- The company self-describes as 'the nation's largest healthcare communication network,' and its network connects nearly 160,000 provider organizations across all U.S. care settings.
Partnerships
- Kno2 has an active and growing technology partnership ecosystem.
- Major named partnerships include Redox (October 2025 strategic alliance for combined data exchange and transformation), NextGen Healthcare (September 2025, enabling 100,000+ providers on TEFCA), PointClickCare (expanded partnership December 2024), RXNT (December 2025 QHIN/TEFCA integration), Net Health, CareEvolution (data enrichment/FHIR, 2023), and CareQuest Innovation Partners (dental HIE initiative, 2026).
Company Size & Ownership
- Kno2 was founded in 2009 (originally as Inofile, rebranded to Kno2 in 2015) and has approximately 51–57 employees as of 2026, making it a small but specialized firm.
- Estimated annual revenue is approximately $9.5–$10M based on third-party data sources, though some estimates place it as high as $25–50M as the company has grown.
Compliance & Certifications
- Kno2 holds HITRUST Risk-Based, two-year (r2) Certification — the highest tier of HITRUST certification — for its Kno2fy communication platform, achieved in February 2024 in collaboration with ecfirst, a HITRUST Authorized External Assessor.
- The company is also HIPAA-compliant by design, with its network built to support the exchange of protected health information under HIPAA requirements.
Compiled from public sources by VenSearch · Last researched October 14, 2026
Offerings
13 offeringsCarequality Connectivity
Access to the Carequality interoperability framework as part of Kno2's full-stack communication network, enabling query-based document exchange with participating health systems and providers nationwide. Kno2 is a Carequality implementor, and this connectivity is available to partners through a single integration with the Kno2 Communication API. It allows organizations to access comprehensive clinical information from the Carequality network without managing a separate connection.
Direct Secure Messaging
A connectivity channel supported within the Kno2 network that enables secure, standards-based electronic messaging for clinical information exchange between providers, health systems, and other healthcare organizations. It is available as part of Kno2's full-stack communication network and accessible via both the Communication API and the Kno2fy portal. It integrates with EHR workflows and supports transitions of care and other clinical communication use cases.
Electronic Signing
An electronic signing capability offered as part of the Kno2 communication network that supports patient consent, care plan and order signing, and provider eSigning workflows. It is integrated within Kno2fy and available to organizations connecting via the Kno2 Communication API. The feature allows organizations to connect tools such as DocuSign through their Kno2fy account.
Health Information Exchange (HIE) Connectivity
A connectivity capability that enables simple and automated submission of ADT notifications and relevant clinical information to regional and local Health Information Exchanges. Kno2 establishes, verifies, and enables the HIE connectivity on behalf of its customers. This is accessible through both the Communication API and the Kno2fy portal.
HL7 FHIR Connectivity
Support for HL7 FHIR-based clinical data exchange as part of the Kno2 communication network, enabling query and retrieval of patient records from hospitals, health systems, clinics, and physician offices on demand. This connectivity is available through Kno2's Communication API and Kno2fy portal. It allows technology vendors and providers to access structured clinical data without building separate FHIR integrations.
HL7 V2.x Connectivity
Support for HL7 Version 2.x messaging standards within the Kno2 communication network, enabling exchange of clinical data using legacy HL7 formats. This connectivity is accessible through Kno2's Communication API and is part of the company's full-stack network supporting multiple interoperability standards. It allows organizations to exchange information using established HL7 V2 message types alongside more modern standards.
Interoperable Cloud Faxing
A cloud fax solution that integrates faxing into interoperability workflows, EHRs, and clinical systems by infusing standards such as C-CDA, FHIR, and Direct Secure Messaging into fax communication. It connects to the world's largest fax providers for reliability and redundancy, supports fax number porting, document management tools, barcode-based Track the Fax reconciliation workflows, and plug-and-play EHR integration. It is accessible through both the Kno2 Communication API and the Kno2fy portal.
Kno2 Communication API
A single REST-based API integration that connects EHRs, health IT platforms, payers, and other healthcare technology vendors to Kno2's full-stack communication network. Through one connection, partners gain access to all communication channels and networks including TEFCA, Carequality, Direct Secure Messaging, FHIR, HL7, cloud fax, and referral networks without needing to build separate integrations for each. It supports Send, Receive, and Find routes for comprehensive clinical information exchange.
Kno2fy Portal
A turnkey, web-based, HIPAA-compliant communication portal that centralizes and manages all major forms of patient information sharing in a single subscription. It allows healthcare organizations to send, receive, and find patient information across national networks regardless of the recipient's EHR or preferred communication method. Features include QC tools for document management, provider directory lookup, auditing and reporting, referral tracking, EHR plug-and-play integration, and enterprise features such as single sign-on and private label options.
QHIN Services (TEFCA)
As a federally designated Qualified Health Information Network (QHIN) under TEFCA, Kno2 provides comprehensive, on-demand access to clinical information from TEFCA participants through its Communication API. This enables partners to participate in TEFCA-based information exchange without building a direct QHIN connection themselves. Kno2 is among the first organizations to receive federal QHIN designation and has pledged to the CMS Aligned Networks initiative.
Referral Networks & 360X Connectivity
Connectivity to referral networks including Careport and NaviHealth, as well as support for Closed-Loop 360X Referral Management workflows. This capability supports referral automation, referral acceptance and follow-up tracking, and transitions of care communication. It is available to EHRs, health platforms, and providers through the Kno2 Communication API and Kno2fy portal.
Solutions for Providers
A set of communication and interoperability solutions designed for healthcare provider organizations ranging from large health systems to single-provider offices and social services organizations. Providers can access national networks, cloud faxing, Direct Secure Messaging, Carequality, HIEs, referral networks, and eSigning tools through either the Kno2fy portal or Kno2-connected technology already integrated into their existing systems. The solution is designed to centralize disparate communication workflows and reduce administrative burden across clinical and operational use cases.
Solutions for Technology Vendors
A solution set built around the Kno2 Communication API that enables EHRs, digital health platforms, patient engagement applications, remote patient monitoring platforms, social determinants of health companies, value-based care and population health organizations, office technology vendors, and chart retrieval organizations to connect to the healthcare ecosystem through a single integration. Technology vendors can rapidly add interoperability capabilities to their products including fax, Direct Secure Messaging, FHIR, and query-based document exchange without building individual connections. Kno2 handles the connectivity infrastructure so vendor partners can focus on their own product workflows and user experience.
Considering Kno2?
Our team will work with you to determine if Kno2 is the right fit for your organization. From research and assessment through procurement negotiation and ongoing vendor management — we handle the entire process at no cost to you.